Essentials
A list of good things that are somewhat underexposed
Information
1) gigapedia.com (The future; you need a google account to sign up.)
2) wordnik.com (The awesome Century Dictionary digitized. For the DJVU scanned version, look here)
Academia
1) academia.edu
Software
1) Jdownloader (automates downloading from filesharing sites like rapidshare, ifile.it, etc.)
2) WinDJVU (The open source viewer for DJVU, a superior scanned-image format. Used for ebooks and archives.)
3) HostsMAN (Great proactive ad blocker and crap filter. Updates your hosts file to sync with blacklists)
4) foobar2000 (The best audio player. Open source.)
5) Foxit and Tracker (Two decent, but sadly commercial, PDF readers; alternatives to the vile Adobe Reader)
Film
1) DVDbeaver (The best movie release comparison site)
2) Movielens (Impressive likeminds system for film)
Time Wasting
1) Them Thangs (Justin Blyth's uplifting photo blog)
2) FreeRice (vocabulary-building game)